Influence of additives on swelling and mucoadhesion properties of glyceryl monooleate liquid crystals

Liquid crystalline systems of glyceryl monooleate/water are used as drug delivery due to their complex structure that controls diffusion. Mucoadhesive properties monooleate suggest it can be for buccal delivery. Using additives is a strategy modify physical and chemical liquid optimize performance system. However, the presence significantly alter such phase behavior, swelling mucoadhesion. Our aim investigate influence on mucoadhesion monooleate-based crystals, intending them systems. The were characterized regarding mesophases, rate, All studied able absorb water presented mucoadhesion, which interesting development Additives induced transitions affected performance, while mucoadhesive poorly affected. Propylene glycol increased uptake, oleic acid transition hexagonal reduced rate. association (5%) propylene (10%) resulted in cubic system with strong potential carrier